Where would the nano size vs a monoatomic size come into preference? Since a mono silver water atom's stability staying solo, and that just because the silver water atom is grouped as solo atoms, does that give them the ability to naturally by pass a pathogens atomic structure? Wouldnt that hypothesis mean that the siver atoms would fall out of any container? Unless one is refering to the unballanced charge state, and wouldnt that naturally group the atoms into larger multi atom sizes making it no different than the other products of less than nano sized siver water?
It is my understanding that the research literature says that silver's action on pathogens is 'similar' to a leukocytes use of H2O2 (Hydrogen-Peroxid)
as an electron stealer in the body, so that it isnt necessary for the agent to enter the pathogen, only for it to come into contact. Furthermore if a single E Coli bacterium is 7 μm(micron) long and 1.8 μm in diameter, than the smaller micro sized .0008μm silver particles would have no problem interfacing with it and evan many of the larger sized silver particles would have some chance of a small activating interface. While the larger particle would have less success with the very small sized Staph A. bacterium, seeing as how it is the interface of their surfaces that is of importance than the evan smaller size silver particles again would be quite able to provoke the death spiral in the bacterium.
I see that research has indicated the advantage of eventual pathogen membrane invasion, but I wonder exactly how necessary that would be seeing as how so many researchers have reported silver's affect on surface contact alone.
from: How Colloidal Silver
Copyright (c) W. G. Peters 2015
Any--- silver particles which make it into circulation can kill a pathogen. These particles (may be) too large to enter into (a) healthy cell through the ion channels, and they are also repelled by healthy cells by virtue of their similar electric charge (Zeta potential). This means that silver nanoparticles will not attack healthy normal human cells. On the other hand, they are attracted to bacteria when they are in close proximity by their difference in electric charge.
It is clear that a silver nanoparticle has to be in very close proximity to a bacterium to have any effect at all. It must be close enough to exchange electrons, as all chemical reactions involve the exchange of electrons. Silver--- is the most conductive of all elements because it has the most mobile surface electrons. As a (silver particle) approaches a bacterium, it will be electrostatically attracted to the bacterium, pulling it closer. As it approaches, the electric field strength (volts per nanometer) increases until an electron from the silver particle can jump to the surface of the pathogen--. When this happens, it weakens and bursts the wall of the pathogen. At the same time, the silver atom that lost its electron is oxidized to a silver ion releasing it from the particle, and the silver ion can then enter the pathogen to damage it. It make take more than one electron exchange to penetrate the pathogen, but a silver nanoparticle contains thousands of silver atoms.
Bactericidal Actions of a Silver Ion Solution on Escherichia coli, Studied by Energy-Filtering Transmission Electron Microscopy and Proteomic Analysis
November 2005 in the journal, Applied and Environmental Microbiology
"The---results indicate that one of the major bactericidal actions of the silver ion is caused by its interaction with the ribosome and subsequent suppression in the expression of enzymes and proteins essential to ATP production. In other words, the silver ions infiltrate the bacterial cell and destroy the ability of the bacteria to generate life-giving energy from the inside."
From the 2015 Hebrew University report:chemist David Avnir of the Hebrew University of Jerusalem, the senior author of the new study
"When silver comes into contact with a bacterium, silver ions begin attaching to the cell wall of the pathogen, releasing nascent oxygen, which in turn inactivates the pathogen through a process called catalytic oxidation."
"Similar to the way hydrogen peroxide works, i.e., a burst of oxygen is transferred electro-chemically from the silver to the pathogen, stunning and partially disabling it."
"Then, the catalytic oxidation causes a series of chemical changes to the cell wall of the pathogen. These chemical changes block the pathogen’s energy transfer and respiration systems."
"Next, the silver ruptures the weakened cell wall of the bacterium, and is absorbed into it, at which point it damages the pathogen’s DNA, preventing it from replicating. Since the bacterium can no longer replicate, the infection can no longer spread."
"Finally, with all of this damage, the bacterium eventually dies."
"Next hundreds of tiny silver micro-particles inside the bodies of dead bacteria are then leached to live bacteria in the same colony, killing them as well.
Once a bacterium is killed by silver it acts like a sponge, continuing to attract and absorb tiny silver particles from its surroundings."
"The dead bacteria killed by the tiny silver particles “infect” the remaining live bacteria in the colony with the silver they’ve absorbed, thereby killing them as well."
Combining Dmso with Silver water may aplicable to this discussion of Silver waters different types efficacies.